{"product_id":"f47912-0-4ml","title":"SLUG Antibody (SNAI2)","description":"SNAI2\/SLUG is a transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting \u003ca href=\"..\/search_result.php?search_txt=ctbp\"\u003eCTBP1\u003c\/a\u003e and \u003ca href=\"..\/search_result.php?search_txt=hdac1\"\u003eHDAC1\u003c\/a\u003e in breast cells. In epidermal keratinocytes, binds to the E-box in \u003ca href=\"..\/search_result.php?search_txt=itga3\"\u003eITGA3\u003c\/a\u003e promoter and represses its transcription. Involved in the regulation of \u003ca href=\"..\/search_result.php?search_txt=itgb1\"\u003eITGB1\u003c\/a\u003e and \u003ca href=\"..\/search_result.php?search_txt=itgb4\"\u003eITGB4\u003c\/a\u003e expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses \u003ca href=\"..\/search_result.php?search_txt=e-cadherin\"\u003eE-Cadherin\u003c\/a\u003e\/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. [UniProt]","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml \/ Rabbit","offer_id":49477900140824,"sku":"F47912-0.4ML","price":429.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_0c891db6-fb08-43ce-98f5-bf30031d559d.jpg?v=1734502843","url":"https:\/\/danabiosci.com\/products\/f47912-0-4ml","provider":"Dana Bioscience","version":"1.0","type":"link"}