{"product_id":"es8796","title":"CD275 rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e IHC;IF;ELISA\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human;Rat;Mouse;\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e IHC-p 1:50-200, ELISA 1:10000-20000\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e Synthetic peptide from human protein at AA range: 201-250\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 23308\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e O75144\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Cell membrane ; Single-pass type I membrane protein .\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e ICOS ligand (B7 homolog 2;B7-H2;B7-like protein Gl50;B7-related protein 1;B7RP-1;CD antigen CD275)\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e alternative products:Additional isoforms seem to exist,function:Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.,induction:Constitutive expression is further enhanced by treatment with TNF-alpha in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells.,sequence caution:The sequence differs from that shown in position 300 onward for unknown reason.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the immunoglobulin superfamily. BTN\/MOG family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,tissue specificity:Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.,","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50411664507160,"sku":"ES8796","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/ES8796-c-1.jpg?v=1751093725","url":"https:\/\/danabiosci.com\/products\/es8796","provider":"Dana Bioscience","version":"1.0","type":"link"}