{"product_id":"es8500","title":"CYFIP2 rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e WB;ELISA\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human;Mouse;Rat\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e WB 1:500-2000, ELISA 1:10000-20000\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e Synthesized peptide derived from CYFIP2 at AA range: 1171-1220\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eObserved_band(KD):\u003c\/strong\u003e 150+45kD\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 26999\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e Q96F07\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Cell junction, synapse, synaptosome . Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118). .\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level).,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10\/HSPC300, NCKAP1 and WASF1\/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50411606966552,"sku":"ES8500","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/ES8500-c-1.jpg?v=1751092716","url":"https:\/\/danabiosci.com\/products\/es8500","provider":"Dana Bioscience","version":"1.0","type":"link"}