{"product_id":"es7939","title":"ERI1 rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e WB;ELISA\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human;Mouse;Rat\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e Western Blot: 1\/500 - 1\/2000. ELISA: 1\/5000. Not yet tested in other applications.\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e The antiserum was produced against synthesized peptide derived from human ERI1. AA range:261-310\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eObserved_band(KD):\u003c\/strong\u003e 37kD\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 90459\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e Q8IV48\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Cytoplasm . Nucleus . Nucleus, nucleolus .\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e ERI1; 3'EXO; THEX1; 3'-5' exoribonuclease 1; 3'-5' exonuclease ERI1; Eri-1 homolog; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; Protein 3'hExo; HEXO\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of SLBP prevents the exonuclease activity.,function:RNA exonuclease that binds to the 3'-end of histone mRNAs and probably degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Required for 5.8S rRNA 3'-end processing.,sequence caution:Translated as Leu.,similarity:Contains 1 exonuclease domain.,similarity:Contains 1 SAP domain.,subunit:Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. Requires the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Also binds to 5.8s ribosomal RNA.,","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50411540906264,"sku":"ES7939","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/ES7939-c-1.jpg?v=1751091448","url":"https:\/\/danabiosci.com\/products\/es7939","provider":"Dana Bioscience","version":"1.0","type":"link"}