{"product_id":"es7496","title":"VEGF-A rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e WB;IF;IHC;ELISA\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human;Mouse;Rat;Pig;Rabbit\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e Western Blot: 1\/500 - 1\/2000.IF: 1:50-200 Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/10000. Not yet tested in other applications.\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e The antiserum was produced against synthesized peptide derived from human VEGF-A. AA range:110-159\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eObserved_band(KD):\u003c\/strong\u003e 21kD(monomer),42kD(dimer)\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 7422\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e P15692\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Secreted . VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e VEGFA; VEGF; Vascular endothelial growth factor A; VEGF-A; Vascular permeability factor; VPF\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e This gene is a member of the PDGF\/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation fro","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50411496571160,"sku":"ES7496","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/ES7496-c-1.jpg?v=1751089837","url":"https:\/\/danabiosci.com\/products\/es7496","provider":"Dana Bioscience","version":"1.0","type":"link"}