{"product_id":"es5572","title":"14-3-3 σ rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e WB;IHC;IF;ELISA\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human;Mouse\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e IHC-p: 100-300.Western Blot: 1\/500 - 1\/2000. ELISA: 1\/20000. Not yet tested in other applications.\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e The antiserum was produced against synthesized peptide derived from human SFN. AA range:41-90\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eObserved_band(KD):\u003c\/strong\u003e 30kD\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 2810\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e P31947\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Cytoplasm. Nucleus . Secreted. May be secreted by a non-classical secretory pathway.\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e SFN; HME1; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt\/mTOR pathway.,function:p53-regulated inhibitor of G2\/M progression.,similarity:Belongs to the 14-3-3 family.,subcellular location:May be secreted by a non-classical secretory pathway.,subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.,tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.,","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50412839534872,"sku":"ES5572","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/ES5572-c-1.jpg?v=1751133986","url":"https:\/\/danabiosci.com\/products\/es5572","provider":"Dana Bioscience","version":"1.0","type":"link"}