{"product_id":"es5237","title":"ZNRF2 rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e IHC;IF;ELISA\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human;Mouse\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/20000. Not yet tested in other applications.\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e The antiserum was produced against synthesized peptide derived from human ZNRF2. AA range:161-210\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 223082\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e Q8NHG8\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Cell junction, synapse, presynaptic cell membrane ; Peripheral membrane protein .\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e ZNRF2; RNF202; E3 ubiquitin-protein ligase ZNRF2; Protein Ells2; RING finger protein 202; Zinc\/RING finger protein 2\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e domain:The RING-type zinc finger domain is required for E3 ligase activity.,function:May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Present in presynaptic plasma membranes in neurons.,subunit:Interacts with UBE2N.,tissue specificity:Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.,","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50411383587096,"sku":"ES5237","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/ES5237-c-1.jpg?v=1751084130","url":"https:\/\/danabiosci.com\/products\/es5237","provider":"Dana Bioscience","version":"1.0","type":"link"}