{"product_id":"es3802","title":"Myosin VI rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e WB;IHC;IF;ELISA\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human;Mouse;Rat\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e Western Blot: 1\/500 - 1\/2000. IHC-p: 1:100-300 ELISA: 1\/5000. Not yet tested in other applications.\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e Synthesized peptide derived from Myosin VI . at AA range: 40-120\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eObserved_band(KD):\u003c\/strong\u003e 149kD\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 4646\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e Q9UM54\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Golgi apparatus . Nucleus . Cytoplasm, perinuclear region . Membrane, clathrin-coated pit . Cytoplasmic vesicle, clathrin-coated vesicle . Cell projection, filopodium . Cell projection, ruffle membrane . Cell projection, microvillus . Cytoplasm, cytosol . Also present in endocyctic vesicles (PubMed:16507995). Translocates from membrane ruffles, endocytic vesicles and cytoplasm to Golgi apparatus, perinuclear membrane and nucleus through induction by p53 and p53-induced DNA damage (PubMed:16507995). Recruited into membrane ruffles from cell surface by EGF-stimulation (PubMed:9852149). Colocalizes with DAB2 in clathrin-coated pits\/vesicles (PubMed:11967127). Colocalizes with OPTN at the Golgi complex and in vesicul\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e MYO6; KIAA0389; Unconventional myosin-VI; Unconventional myosin-6\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e myosin VI(MYO6) Homo sapiens    This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014],","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50411304091928,"sku":"ES3802","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/ES3802-c-1.jpg?v=1751079070","url":"https:\/\/danabiosci.com\/products\/es3802","provider":"Dana Bioscience","version":"1.0","type":"link"}