{"product_id":"es2170","title":"DHRS4 rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e WB;IHC;IF;ELISA\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human;Rat;Mouse;\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/40000. Not yet tested in other applications.\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e The antiserum was produced against synthesized peptide derived from human DHRS4. AA range:191-240\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eObserved_band(KD):\u003c\/strong\u003e 32-34kD\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 10901\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e Q9BTZ2\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e [Isoform 1]: Peroxisome . Isoform 4 is not peroxisomal. .; [Isoform 7]: Nucleus .\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e DHRS4; Dehydrogenase\/reductase SDR family member 4; NADPH-dependent carbonyl reductase\/NADP-retinol dehydrogenase; CR; PHCR; NADPH-dependent retinol dehydrogenase\/reductase; NRDR; humNRDR; Peroxisomal short-chain alcohol dehydrogenase; PSCD\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e catalytic activity:R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.,function:Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones.,miscellaneous:Inhibited by kaempferol, quercetin, genistein and myristic acid.,similarity:Belongs to the short-chain dehydrogenases\/reductases (SDR) family.,subcellular location:Isoform 1 is peroxisomal, while isoform 4 is not.,subunit:Homotetramer.,tissue specificity:Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoforms 5 and 6 are expressed in a few neoplastic cervical tissues.,","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50411181867288,"sku":"ES2170","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/ES2170-c-1.jpg?v=1751073485","url":"https:\/\/danabiosci.com\/products\/es2170","provider":"Dana Bioscience","version":"1.0","type":"link"}