{"product_id":"es20285","title":"BMP-4 rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e WB; ELISA\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human;Rat;Mouse;\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e WB 1:1000-2000 ELISA 1:5000-20000\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e Synthesized peptide derived from human BMP-4 AA range: 261-310\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 652\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e P12644\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Secreted, extracellular space, extracellular matrix.\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e Bone morphogenetic protein 4 (BMP-4;Bone morphogenetic protein 2B;BMP-2B)\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e disease:Defects in BMP4 are the cause of microphthalmia syndromic type 6 (MCOPS6) [MIM:607932]; also known as microphthalmia and pituitary anomalies or microphthalmia with brain and digit developmental anomalies. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia\/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS6 is characterized by microphthalmia\/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies.,function:Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair.,online information:Bone morphogenetic protein 4 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked (By similarity). Interacts with GREM2 (By similarity) and SOSTDC1. Part of a complex consisting of TWSG1 and CHRD.,tissue specificity:Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.,","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50413706445080,"sku":"ES20285","price":250.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/danabiosci.com\/products\/es20285","provider":"Dana Bioscience","version":"1.0","type":"link"}