{"product_id":"es20059","title":"C\/EBP β (Acetyl Lys265) rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e WB; ELISA\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human;Mouse;Rat\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e WB 1:1000-2000 ELISA 1:5000-20000\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e Synthesized peptide derived from human C\/EBP β (Acetyl Lys265)\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eObserved_band(KD):\u003c\/strong\u003e 40kD\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 1051\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e P17676\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Nucleus . Cytoplasm . Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity). .\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e CCAAT\/enhancer-binding protein beta (C\/EBP beta;Liver activator protein;Nuclear factor NF-IL6;Transcription factor 5;TCF-5)\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e function:Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'.,PTM:Sumoylated by polymeric chains of SUMO2 or SUMO3.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. C\/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C\/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2.,tissue specificity:Expressed at low levels in the lung, kidney and spleen.,","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50413659521304,"sku":"ES20059","price":250.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/danabiosci.com\/products\/es20059","provider":"Dana Bioscience","version":"1.0","type":"link"}