{"product_id":"es1464","title":"LIMK-1\/2 (phospho Thr508\/505) rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e WB;IHC;IF;ELISA\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human;Mouse;Rat\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e WB 1:500-2000;IHC-p 1:100-500;IF\/ICC 1:100-500;ELISA 1:5000-20000\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e Synthesized phospho-peptide around the phosphorylation site of human LIMK-1\/2 (phospho Thr508\/505)\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eObserved_band(KD):\u003c\/strong\u003e 72kD\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 3984\/3985\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e P53667\/P53671\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Cytoplasm . Nucleus . Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Predominantly found in the cytoplasm. Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B\/LRAP25-dependent manner. .\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e LIMK1; LIMK; LIM domain kinase 1; LIMK-1; LIMK2; LIM domain kinase 2; LIMK-2\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine\/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cog","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50411109810456,"sku":"ES1464","price":250.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/danabiosci.com\/products\/es1464","provider":"Dana Bioscience","version":"1.0","type":"link"}