{"product_id":"es14162","title":"PEN2 rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e IHC;IF\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human; Mouse;Rat\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e IHC-p 1：50-200\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e Synthesized peptide derived from human PEN2 AA range: 51-101\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 55851\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e Q9NZ42\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . Predominantly located in the endoplasmic reticulum and in the cis-Golgi. .\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50413380829464,"sku":"ES14162","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/ES14162-c-1.jpg?v=1751147822","url":"https:\/\/danabiosci.com\/products\/es14162","provider":"Dana Bioscience","version":"1.0","type":"link"}