{"product_id":"es13314","title":"RUBIC rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e WB\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human; Mouse\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e WB 1:500-2000\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e Synthesized peptide derived from human RUBIC AA range: 868-918\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eObserved_band(KD):\u003c\/strong\u003e 105kD\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 9711\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e Q92622\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Late endosome . Lysosome . Early endosome . Predominantly located in late endosomes\/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e Run domain Beclin-1 interacting and cystein-rich containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron)\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50413345603864,"sku":"ES13314","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/ES13314-c-1.jpg?v=1751146614","url":"https:\/\/danabiosci.com\/products\/es13314","provider":"Dana Bioscience","version":"1.0","type":"link"}