{"product_id":"em1275","title":"Cystatin C (7F11) Mouse mAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e WB, IHC, ELISA\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Mouse\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e WB  1:1,000-2,000     IHC 1:100-200     ELISA  1:10,000-20,000\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e Recombinant Protein\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Monoclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG1\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1mg\/mL\u003cbr\u003e\u003cstrong\u003eObserved_band(KD):\u003c\/strong\u003e 14kDa\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 1471\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e P01034\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Secreted\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e AD8, Cystatin3, Gamma trace, HCCAA\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e Cystatin C is a 13-kDa inhibitor of cysteine proteinases which is secreted by all cell types and is completely cleared from the organism through glomerular filtration, shown to be an early and sensitive biomarker of renal dysfunction. A mutation in Cystatin C has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus.","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50411051057432,"sku":"EM1275","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/EM1275-c-1.jpg?v=1751069470","url":"https:\/\/danabiosci.com\/products\/em1275","provider":"Dana Bioscience","version":"1.0","type":"link"}