{"product_id":"em1041","title":"Bcl-2 Mouse mAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e WB, IHC, IF\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human, Rat, Mouse\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Mouse\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e WB 1:1,000-2,000 IHC 1:200 IF 1:100-200\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e Synthetic Peptide\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Monoclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG1\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1mg\/mL\u003cbr\u003e\u003cstrong\u003eObserved_band(KD):\u003c\/strong\u003e 26kDa\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 596\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e P10415\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Mitochondrion outer membrane,Nucleus membrane,Endoplasmic reticulum membrane\u003cbr\u003e\u003cstrong\u003eOther_name:\u003c\/strong\u003e B-Cell Leukemia\/Lymphoma 2 ;B-Cell CLL\/Lymphoma 2\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability.","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":50411023106328,"sku":"EM1041","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/EM1041-c-1.jpg?v=1751068815","url":"https:\/\/danabiosci.com\/products\/em1041","provider":"Dana Bioscience","version":"1.0","type":"link"}