{"product_id":"dusp4-polyclonal-antibody-abcb06411","title":"DUSP4 Polyclonal Antibody","description":"\u003ch4\u003eAb type\u003c\/h4\u003e\u003cp\u003ePrimary antibody\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eThe protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine\/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK\/ERK| SAPK\/JNK| p38)| which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases| different tissue distribution and subcellular localization| and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1| ERK2 and JNK| is expressed in a variety of tissues| and is localized in the nucleus. Two alternatively spliced transcript variants| encoding distinct isoforms| have been obser\u003c\/p\u003e\u003ch4\u003eReactivity\u003c\/h4\u003e\u003cp\u003eHuman, Mouse, Rat\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eHost\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eSynthesized peptide derived from human DUSP4 Polyclonal\u003c\/p\u003e\u003ch4\u003eStorage Stability\u003c\/h4\u003e\u003cp\u003e-20°C for 1 year\u003c\/p\u003e\u003ch4\u003eConcentration\u003c\/h4\u003e\u003cp\u003e1 mg\/ml\u003c\/p\u003e\u003ch4\u003eMolecularWeight_Da\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003esynonyms\u003c\/h4\u003e\u003cp\u003eDual specificity protein phosphatase 4;EC 3.1.3.16;EC 3.1.3.48;Dual specificity protein phosphatase hVH2;Mitogen-activated protein kinase phosphatase 2;MAP kinase phosphatase 2;MKP-2; Dual specificity protein phosphatase 4; EC 3.1.3.16; EC 3.1.3.48; Dual specificity protein phosphatase hVH2; Mitogen-activated protein kinase phosphatase 2; MAP kinase phosphatase 2; MKP-2\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42404464460010,"sku":"ABCB06411","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_92fb45e5-3d0f-4a2b-9122-f41ac9b0793b.png?v=1645221773","url":"https:\/\/danabiosci.com\/products\/dusp4-polyclonal-antibody-abcb06411","provider":"Dana Bioscience","version":"1.0","type":"link"}