{"product_id":"dkk3-antibody-biotin-conjugated-abccs43479","title":"DKK3 Antibody, Biotin conjugated","description":"\u003ch4\u003eSize\u003c\/h4\u003e\u003cp\u003e100ug\u003c\/p\u003e\u003ch4\u003eClone Number\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eAliases\u003c\/h4\u003e\u003cp\u003eDickkopf 3 antibody; Dickkopf 3 homolog (Xenopus laevis) antibody; Dickkopf 3 homolog antibody; Dickkopf homolog 3 antibody; Dickkopf related protein 3 antibody; Dickkopf related protein 3 Precursor antibody; Dickkopf WNT signaling pathway inhibitor 3 antibody; Dickkopf; Xenopus; homolog of; 3 antibody; Dickkopf-3 antibody; Dickkopf-related protein 3 antibody; Dickkopf3 antibody; DKK 3 antibody; Dkk-3 antibody; DKK3 antibody; DKK3_HUMAN antibody; hDkk 3 antibody; hDkk-3 antibody; hDkk3 antibody; Regulated in glioma antibody; REIC antibody; RIG antibody; RIG-like 5-6 antibody; RIG-like 7-1 antibody\u003c\/p\u003e\u003ch4\u003eImmunogen Species\u003c\/h4\u003e\u003cp\u003eHomo sapiens (Human)\u003c\/p\u003e\u003ch4\u003eUniProt ID\u003c\/h4\u003e\u003cp\u003eQ9UBP4\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eRecombinant Human Dickkopf-related protein 3 protein (22-350AA)\u003c\/p\u003e\u003ch4\u003eRaised in\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eSpecies Reactivity\u003c\/h4\u003e\u003cp\u003eHuman\u003c\/p\u003e\u003ch4\u003eTested Applications\u003c\/h4\u003e\u003cp\u003eELISA\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eAntagonizes canonical Wnt signaling by inhibiting LRP5\/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5\/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003ePurification Method\u003c\/h4\u003e\u003cp\u003e\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003ch4\u003eConjugate\u003c\/h4\u003e\u003cp\u003eBiotin\u003c\/p\u003e\u003ch4\u003eBuffer\u003c\/h4\u003e\u003cp\u003ePreservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, PH 7.4\u003c\/p\u003e\u003ch4\u003eForm\u003c\/h4\u003e\u003cp\u003eLiquid\u003c\/p\u003e\u003ch4\u003eStroage\u003c\/h4\u003e\u003cp\u003eUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003ch4\u003eTarget Names\u003c\/h4\u003e\u003cp\u003eDKK3\u003c\/p\u003e\u003ch4\u003eResearch Areas\u003c\/h4\u003e\u003cp\u003eSignal transduction; Stem cells\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"Default Title","offer_id":42364160540906,"sku":"ABCCS43479","price":299.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_b684d62c-283f-41c4-8aa6-6b4fa5f0236d.png?v=1650897328","url":"https:\/\/danabiosci.com\/products\/dkk3-antibody-biotin-conjugated-abccs43479","provider":"Dana Bioscience","version":"1.0","type":"link"}