{"product_id":"ddb1-monoclonal-antibody-abccs00819","title":"DDB1 Monoclonal Antibody","description":"\u003ch4\u003eSize\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eClone Number\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eAliases\u003c\/h4\u003e\u003cp\u003eDamage specific DNA binding protein 1; Damage-specific DNA-binding protein 1; DDB 1; DDB p127 subunit; Ddb1; DDB1_HUMAN; DDBa; DNA damage binding protein 1; DNA damage-binding protein 1; DNA damage-binding protein a; HBV X-associated protein 1;\u003c\/p\u003e\u003ch4\u003eImmunogen Species\u003c\/h4\u003e\u003cp\u003eHuman\u003c\/p\u003e\u003ch4\u003eUniProt ID\u003c\/h4\u003e\u003cp\u003eQ16531\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003ePurified recombinant human DDB1 protein fragments expressed in E.coli.\u003c\/p\u003e\u003ch4\u003eRaised in\u003c\/h4\u003e\u003cp\u003eMouse\u003c\/p\u003e\u003ch4\u003eSpecies Reactivity\u003c\/h4\u003e\u003cp\u003eHuman,Mouse,Rat,Monkey\u003c\/p\u003e\u003ch4\u003eTested Applications\u003c\/h4\u003e\u003cp\u003eELISA,WB;Recommended dilution:WB:1:500-1:5000\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eRequired for DNA repair.Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex).The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair.The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD),6-4 photoproducts (6-4 PP),apurinic sites and short mismatches.Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1.DCX(DDB2) (also known as DDB1-CUL4-ROC1,CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A,histone H3 and histone H4 at sites of UV-induced DNA damage.The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair.DCX(DDB2) also ubiquitinates XPC,which may enhance DNA-binding by XPC and promote NER.DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication.DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR).May also play a role in ubiquitination of CDKN1B\/p27kip when associated with CUL4 and SKP2.\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003eMonoclonal\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG2b\u003c\/p\u003e\u003ch4\u003ePurification Method\u003c\/h4\u003e\u003cp\u003eAffinity purified\u003c\/p\u003e\u003ch4\u003eConjugate\u003c\/h4\u003e\u003cp\u003eNon-conjugated\u003c\/p\u003e\u003ch4\u003eBuffer\u003c\/h4\u003e\u003cp\u003eAscites\u003c\/p\u003e\u003ch4\u003eForm\u003c\/h4\u003e\u003cp\u003eliquid\u003c\/p\u003e\u003ch4\u003eStroage\u003c\/h4\u003e\u003cp\u003eUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003ch4\u003eTarget Names\u003c\/h4\u003e\u003cp\u003eDDB1\u003c\/p\u003e\u003ch4\u003eResearch Areas\u003c\/h4\u003e\u003cp\u003eEpigenetics and Nuclear Signaling\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"Default Title","offer_id":42978539602154,"sku":"ABCCS00819","price":384.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_f296d04e-f904-4f15-8bbc-526ada389526.png?v=1653405132","url":"https:\/\/danabiosci.com\/products\/ddb1-monoclonal-antibody-abccs00819","provider":"Dana Bioscience","version":"1.0","type":"link"}