{"product_id":"cxcl12-antibody-abccs65225","title":"CXCL12 Antibody","description":"\u003ch4\u003eSize\u003c\/h4\u003e\u003cp\u003e100ul\u003c\/p\u003e\u003ch4\u003eClone Number\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eAliases\u003c\/h4\u003e\u003cp\u003e12-O-tetradecanoylphorbol 13-acetate repressed protein 1 antibody; AI174028 antibody; C-X-C motif chemokine 12 antibody; Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) antibody; Chemokine (C-X-C motif) ligand 12 antibody; Chemokine CXC motif ligand 12 antibody; cxcl12 antibody; hIRH antibody; hSDF-1 antibody; Intercrine reduced in hepatomas antibody; IRH antibody; OTTHUMP00000019491 antibody; PBSF antibody; Pre-B cell growth-stimulating factor antibody; SCYB12 antibody; SDF 1 antibody; SDF-1 antibody; SDF-1-alpha(3-67) antibody; SDF-1a antibody; SDF-1b antibody; SDF1_HUMAN antibody; SDF1A antibody; SDF1B antibody; Stromal cell-derived factor 1 antibody; Stromal cell-derived factor 1 delta antibody; Stromal cell-derived factor 1 gamma antibody; Stromal cell-derived factor 1a antibody; Stromal cell-derived factor-1 alpha antibody; Thymic lymphoma cell-stimulating factor antibody; Tlsf antibody; TLSF-a antibody; TLSF-b antibody; Tlsfa antibody; Tlsfb antibody; TPAR1 antibody\u003c\/p\u003e\u003ch4\u003eImmunogen Species\u003c\/h4\u003e\u003cp\u003eHomo sapiens (Human)\u003c\/p\u003e\u003ch4\u003eUniProt ID\u003c\/h4\u003e\u003cp\u003eP48061\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eRecombinant Human Stromal cell-derived factor 1 protein (22-89AA)\u003c\/p\u003e\u003ch4\u003eRaised in\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eSpecies Reactivity\u003c\/h4\u003e\u003cp\u003eHuman\u003c\/p\u003e\u003ch4\u003eTested Applications\u003c\/h4\u003e\u003cp\u003eELISA, IHC; Recommended dilution: IHC:1:20-1:200\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eChemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A\/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003ePurification Method\u003c\/h4\u003e\u003cp\u003e\u0026gt;95%, Antigen Affinity purified \u0026amp; Affinity purified\u003c\/p\u003e\u003ch4\u003eConjugate\u003c\/h4\u003e\u003cp\u003eNon-conjugated\u003c\/p\u003e\u003ch4\u003eBuffer\u003c\/h4\u003e\u003cp\u003ePreservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003ch4\u003eForm\u003c\/h4\u003e\u003cp\u003eLiquid\u003c\/p\u003e\u003ch4\u003eStroage\u003c\/h4\u003e\u003cp\u003eUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003ch4\u003eTarget Names\u003c\/h4\u003e\u003cp\u003eCXCL12\u003c\/p\u003e\u003ch4\u003eResearch Areas\u003c\/h4\u003e\u003cp\u003eOthers\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"Default Title","offer_id":42250672079082,"sku":"ABCCS65225","price":299.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_7973e5a7-6636-49c3-b7ed-f37223c9f5bd.png?v=1650625806","url":"https:\/\/danabiosci.com\/products\/cxcl12-antibody-abccs65225","provider":"Dana Bioscience","version":"1.0","type":"link"}