{"product_id":"cnga3-antibody-abccs45481","title":"CNGA3 Antibody","description":"\u003ch4\u003eSize\u003c\/h4\u003e\u003cp\u003e100ul\u003c\/p\u003e\u003ch4\u003eClone Number\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eAliases\u003c\/h4\u003e\u003cp\u003eACHM2 antibody; CCNC1 antibody; CCNCa antibody; CCNCalpha antibody; CNCG3 antibody; CNG 3 antibody; CNG channel alpha 3 antibody; CNG channel alpha-3 antibody; CNG-3 antibody; CNG3 antibody; CNGA3 antibody; Cnga3 cyclic nucleotide gated channel alpha 3 antibody; CNGA3_HUMAN antibody; Cone photoreceptor cGMP gated channel antibody; Cone photoreceptor cGMP gated channel alpha subunit antibody; Cone photoreceptor cGMP gated channel subunit alpha antibody; Cone photoreceptor cGMP-gated channel subunit alpha antibody; Cyclic nucleotide gated cation channel alpha 3 antibody; Cyclic nucleotide gated channel alpha 3 antibody; Cyclic nucleotide gated channel olfactory 3 antibody; Cyclic nucleotide gated channel rod photoreceptor subunit alpha antibody; Cyclic nucleotide-gated cation channel alpha-3 antibody; Cyclic nucleotide-gated channel alpha-3 antibody; OTTHUMP00000161120 antibody\u003c\/p\u003e\u003ch4\u003eImmunogen Species\u003c\/h4\u003e\u003cp\u003eHomo sapiens (Human)\u003c\/p\u003e\u003ch4\u003eUniProt ID\u003c\/h4\u003e\u003cp\u003eQ16281\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eRecombinant Human Cyclic nucleotide-gated cation channel alpha-3 protein (1-165AA)\u003c\/p\u003e\u003ch4\u003eRaised in\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eSpecies Reactivity\u003c\/h4\u003e\u003cp\u003eHuman\u003c\/p\u003e\u003ch4\u003eTested Applications\u003c\/h4\u003e\u003cp\u003eELISA, IHC; Recommended dilution: IHC:1:20-1:200\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eVisual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003ePurification Method\u003c\/h4\u003e\u003cp\u003eAntigen Affinity Purified\u003c\/p\u003e\u003ch4\u003eConjugate\u003c\/h4\u003e\u003cp\u003eNon-conjugated\u003c\/p\u003e\u003ch4\u003eBuffer\u003c\/h4\u003e\u003cp\u003ePBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003ch4\u003eForm\u003c\/h4\u003e\u003cp\u003eLiquid\u003c\/p\u003e\u003ch4\u003eStroage\u003c\/h4\u003e\u003cp\u003eUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003ch4\u003eTarget Names\u003c\/h4\u003e\u003cp\u003eCNGA3\u003c\/p\u003e\u003ch4\u003eResearch Areas\u003c\/h4\u003e\u003cp\u003eNeuroscience\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"Default Title","offer_id":42350222311658,"sku":"ABCCS45481","price":299.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_dc091447-8e2a-4fda-969e-dc79f337026f.png?v=1650901336","url":"https:\/\/danabiosci.com\/products\/cnga3-antibody-abccs45481","provider":"Dana Bioscience","version":"1.0","type":"link"}