{"product_id":"calcoco2-antibody-abccs45772","title":"CALCOCO2 Antibody","description":"\u003ch4\u003eSize\u003c\/h4\u003e\u003cp\u003e100ul\u003c\/p\u003e\u003ch4\u003eClone Number\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eAliases\u003c\/h4\u003e\u003cp\u003eAntigen nuclear dot 52 kDa protein antibody; CACO2_HUMAN antibody; Calcium binding and coiled coil domain 2 antibody; Calcium binding and coiled coil domain containing protein 2 antibody; Calcium-binding and coiled-coil domain-containing protein 2 antibody; CALCOCO 2 antibody; CALCOCO2 antibody; MGC17318 antibody; NDP52 antibody; Nuclear domain 10 protein 52 antibody; Nuclear domain 10 protein antibody; Nuclear domain 10 protein NDP52 antibody; Nuclear domain protein 52 antibody; Nuclear dot protein 52 antibody; OTTHUMP00000218344 antibody; OTTHUMP00000218345 antibody; OTTHUMP00000218346 antibody; OTTHUMP00000218347 antibody; OTTHUMP00000218349 antibody; OTTHUMP00000218351 antibody\u003c\/p\u003e\u003ch4\u003eImmunogen Species\u003c\/h4\u003e\u003cp\u003eHomo sapiens (Human)\u003c\/p\u003e\u003ch4\u003eUniProt ID\u003c\/h4\u003e\u003cp\u003eQ13137\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eRecombinant Human Calcium-binding and coiled-coil domain-containing protein 2 protein (137-446AA)\u003c\/p\u003e\u003ch4\u003eRaised in\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eSpecies Reactivity\u003c\/h4\u003e\u003cp\u003eHuman\u003c\/p\u003e\u003ch4\u003eTested Applications\u003c\/h4\u003e\u003cp\u003eELISA, WB, IHC, IP; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eXenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and\/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003ePurification Method\u003c\/h4\u003e\u003cp\u003eAntigen Affinity Purified\u003c\/p\u003e\u003ch4\u003eConjugate\u003c\/h4\u003e\u003cp\u003eNon-conjugated\u003c\/p\u003e\u003ch4\u003eBuffer\u003c\/h4\u003e\u003cp\u003ePBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003ch4\u003eForm\u003c\/h4\u003e\u003cp\u003eLiquid\u003c\/p\u003e\u003ch4\u003eStroage\u003c\/h4\u003e\u003cp\u003eUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003ch4\u003eTarget Names\u003c\/h4\u003e\u003cp\u003eCALCOCO2\u003c\/p\u003e\u003ch4\u003eResearch Areas\u003c\/h4\u003e\u003cp\u003eImmunology\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"Default Title","offer_id":42350186234090,"sku":"ABCCS45772","price":299.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_feccd100-d29d-41d9-bb3a-17f3fad3e099.png?v=1650901881","url":"https:\/\/danabiosci.com\/products\/calcoco2-antibody-abccs45772","provider":"Dana Bioscience","version":"1.0","type":"link"}