{"product_id":"brcc3-antibody-abccs44846","title":"BRCC3 Antibody","description":"\u003ch4\u003eSize\u003c\/h4\u003e\u003cp\u003e100ul\u003c\/p\u003e\u003ch4\u003eClone Number\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eAliases\u003c\/h4\u003e\u003cp\u003eBRCA1-A complex subunit BRCC36 antibody; BRCA1\/BRCA2 containing complex subunit 3 antibody; BRCA1\/BRCA2 containing complex subunit 36 antibody; BRCA1\/BRCA2-containing complex subunit 3 antibody; BRCA1\/BRCA2-containing complex subunit 36 antibody; Brcc3 antibody; BRCC3_HUMAN antibody; BRCC36 antibody; BRISC complex subunit BRCC36 antibody; C6.1A  antibody; Chromosome X open reading frame 53 antibody; CXorf53 antibody; Lys-63-specific deubiquitinase BRCC36 antibody; OTTHUMP00000061450  antibody\u003c\/p\u003e\u003ch4\u003eImmunogen Species\u003c\/h4\u003e\u003cp\u003eHomo sapiens (Human)\u003c\/p\u003e\u003ch4\u003eUniProt ID\u003c\/h4\u003e\u003cp\u003eP46736\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eRecombinant Human Lys-63-specific deubiquitinase BRCC36 protein (1-316AA)\u003c\/p\u003e\u003ch4\u003eRaised in\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eSpecies Reactivity\u003c\/h4\u003e\u003cp\u003eHuman\u003c\/p\u003e\u003ch4\u003eTested Applications\u003c\/h4\u003e\u003cp\u003eELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eMetalloprotease that specifically cleaves \\\\\\'Lys-63\\\\\\'-linked polyubiquitin chains. Does not have activity toward \\\\\\'Lys-48\\\\\\'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes \\\\\\'Lys-63\\\\\\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes \\\\\\'Lys-63\\\\\\'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves \\\\\\'Lys-63\\\\\\'-linked ubiquitin in various substrates. Mediates the specific \\\\\\'Lys-63\\\\\\'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003ePurification Method\u003c\/h4\u003e\u003cp\u003eAntigen Affinity Purified\u003c\/p\u003e\u003ch4\u003eConjugate\u003c\/h4\u003e\u003cp\u003eNon-conjugated\u003c\/p\u003e\u003ch4\u003eBuffer\u003c\/h4\u003e\u003cp\u003ePBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003ch4\u003eForm\u003c\/h4\u003e\u003cp\u003eLiquid\u003c\/p\u003e\u003ch4\u003eStroage\u003c\/h4\u003e\u003cp\u003eUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003ch4\u003eTarget Names\u003c\/h4\u003e\u003cp\u003eBRCC3\u003c\/p\u003e\u003ch4\u003eResearch Areas\u003c\/h4\u003e\u003cp\u003eEpigenetics and Nuclear Signaling; Cancer; Cell biology\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"Default Title","offer_id":42359237673194,"sku":"ABCCS44846","price":299.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_38c2807b-645d-4440-adf6-abd245cc8c83.png?v=1650900034","url":"https:\/\/danabiosci.com\/products\/brcc3-antibody-abccs44846","provider":"Dana Bioscience","version":"1.0","type":"link"}