{"product_id":"abbkine-prp1122-100g","title":"Human RSPO1\/R-spondin 1 Protein, His-SUMO tag (Animal-Free)","description":"\u003cp\u003e\u003cstrong\u003ePrimary Product Type:\u003c\/strong\u003e Cytokines and proteins\u003c\/p\u003e\u003cp\u003eR-spondin 1 (RSPO1, Roof plate-specific Spondin 1) is a cysteine-rich secreted glycoprotein that belongs to the R-Spondin family. Structurally, R-spondin 1 harbors an N-terminal signal peptide, two cysteine-rich furin-like (FU1-FU2) domains, a thrombospondin (TSP) domain, and a basic amino acid-rich (BR) C-terminal domain. R-spondin 1 acts as a ligand for the leucine-rich repeat-containing G-protein coupled receptor (LGR) family (LGR4\/5\/6), subsequent clearing negative regulators ZNRF3\/RNF43 from the membrane, leading to the availability of Wnt receptor and activating Wnt\/β-catenin signaling. The signal cascade is essential for regulating stem cell proliferation, embryonic development, and tissue homeostasis.\u003c\/p\u003e","brand":"Abbkine","offers":[{"title":"100 μg","offer_id":51541455831320,"sku":"PRP1122-100g","price":549.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/abbkine-logo-1_522f9836-60b5-4a18-8e99-1d2b76ce3248.png?v=1768023234","url":"https:\/\/danabiosci.com\/products\/abbkine-prp1122-100g","provider":"Dana Bioscience","version":"1.0","type":"link"}