{"product_id":"abbkine-prp1074-1mg","title":"Human BMP-4 Protein","description":"\u003cp\u003e\u003cstrong\u003ePrimary Product Type:\u003c\/strong\u003e Cytokines and proteins\u003c\/p\u003e\u003cp\u003eBone morphogenetic protein -4 (BMP-4) is one of nine structurally related BMP's, belonging to transforming growth factor-β (TGF-β) superfamily, which secretes proteins. Mature BMP-4 is a dimer that binds to a multimeric transmembrane receptor with serine\/threonine kinase activity. BMP-4 treatment promoted the proliferation of HCC cells and induced autophagy. Mechanism study shows that autophagy induced by BMP-4 is mediated by activating JNK1\/Bcl2 pathway. JNK1 inhibitor and JNK1 knockout can weaken BMP-4-induced autophagy and eliminate BMP-4-promoted HCC cell growth. BMP-4 promotes the proliferation of HCC through autophagy activation of JNK1\/Bcl-2 signaling.\u003c\/p\u003e","brand":"Abbkine","offers":[{"title":"1 mg","offer_id":51541620490520,"sku":"PRP1074-1mg","price":2369.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/abbkine-logo-1_3ec371a5-d1d9-4340-9b74-c9932a5029fd.png?v=1768027377","url":"https:\/\/danabiosci.com\/products\/abbkine-prp1074-1mg","provider":"Dana Bioscience","version":"1.0","type":"link"}