{"product_id":"abbkine-prp1003-5g","title":"Human IL-1α Protein, His tag (Animal-Free)","description":"\u003cp\u003e\u003cstrong\u003ePrimary Product Type:\u003c\/strong\u003e Cytokines and proteins\u003c\/p\u003e\u003cp\u003eInterleukin-1 alpha (IL1 alpha or IL1α) is a member of the interleukin-1 cytokine family, found constitutively present in epithelial layers of the entire gastrointestinal tract, lung, liver, kidney, endothelial cells, and astrocytes. The synthesized IL-1 alpha is a 31 kDa inactive precursor and can be cleaved by intracellular caspase-1 or extracellular proteases to generate the bioactive 17 kDa form and the 16 kDa N-terminal cleavage product. Both precursor and mature IL-1 alpha protein bind to the IL-1 receptor (IL-1R), initiating a cascade of inflammatory cytokines and chemokines production such as IL-6, IL-8, and TNF, in response to viral and bacterial pathogens conditions. IL-1 alpha plays a central role in immune-surveillance mechanisms, stimulating macrophages, neutrophils, and CD8+ T cells activity.\u003c\/p\u003e","brand":"Abbkine","offers":[{"title":"5 μg","offer_id":51541127168280,"sku":"PRP1003-5g","price":69.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/abbkine-logo-1_631446c3-3097-4577-90f8-86bd03cab9b2.png?v=1768017019","url":"https:\/\/danabiosci.com\/products\/abbkine-prp1003-5g","provider":"Dana Bioscience","version":"1.0","type":"link"}