CUSABIO Quarterly Citaion: 1000+ papers, 4000+ impact factor!

Thank you for your continued support of CUSABIO! In the third quarter of 2023, CUSABIO products have contributed to the publication of over 100 research papers, with a cumulative impact factor exceeding 4000+! The total number of publications has now reached 21,400!

We sincerely appreciate your choice of CUSABIO research reagents in your scientific journey. Once again, thank you for your trust and support. We will continue to strive to provide you with better products and services!

Now, let's share the exciting research achievements together!

CUSABIO Quarterly Top 10 Recommended Publications
Top 1

Article Title: Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice

Journal Name: Cancer Cell

Impact Factor: 50.3

CUSABIO Citation Product: Mouse Lipopolysaccharides(LPS) ELISA Kit,CSB-E13066m


Colorectal Cancer (CRC) is a common and deadly malignancy. Alterations in the intestinal microbiota of patients play a pivotal role in influencing the occurrence and progression of CRC. It has been demonstrated that the intake of probiotics that are deficient in the body or their metabolic products is an effective therapeutic approach for CRC.

A study led by Professor Yu Chun's team at The Chinese University of Hong Kong has identified a probiotic - C. maltaromaticum, which can impact the progression of colorectal cancer. They found that it can suppress the occurrence and development of female colorectal cancer patients in an estrogen-dependent manner through the SLC3A2-VDR signaling pathway, providing new insights for the treatment of colorectal cancer.

Top 2

Article Title: NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice

Journal Name: Signal Transduct Target Ther

Impact Factor: 39.3

CUSABIO Citation Product:
Mouse very low density lipoprotein(VLDL)ELISA Kit,CSB-E17089m
Mouse oxidized low density lipoprotein,OxLDL ELISA Kit,CSB-E07933m


Natriuretic peptide receptor C (NPRC) has been shown to have beneficial effects on cardiovascular diseases in animal models, but its role in the pathogenesis of atherosclerosis (AS) is not yet clear. NPRC knockout reduces inflammation and endothelial cell apoptosis, increases eNOS expression, and reduces the size and instability of atherosclerotic lesions in AS by modulating the cAMP/PKA-AKT1 and NF-κB pathways. Therefore, targeting NPRC may provide a promising approach for the prevention and treatment of atherosclerosis.

Top 3

Article Title: Cellular Membrane‐Engineered Nanovesicles as Three‐Stage Booster to Target Lesion Core

Journal Name: Adv Mater

Impact Factor: 29.4

CUSABIO Citation Product: Mouse Atrial Natriuretic Peptide,ANP ELISA Kit,CSB-E04848m


This study has created a nanovesicle called CMEV, comprising three key components that enable the precise delivery of the therapeutic peptide CST to the core of cardiac lesions, improving ischemic cardiomyopathy. Firstly, these vesicles can migrate to damaged tissues akin to neutrophils. Secondly, they accumulate in injured cardiac regions through specific antibodies. Finally, these vesicles' cores contain CST and can release it based on the microenvironment, thereby ameliorating conditions at the core of cardiac lesions, including reducing cardiomyocyte apoptosis, controlling excessive fibrosis, influencing macrophage activity, and promoting neovascularization. This technology holds the potential to significantly enhance the treatment of ischemic cardiomyopathy.

Top 4

Article Title: Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis

Journal Name: Cell Metab

Impact Factor: 29

CUSABIO Citation Product: Mouse Fibroblast growth factor 15(FGF15) ELISA kit,CSB-EL522052MO


Non-alcoholic fatty liver disease (NAFLD) is considered an epidemic affecting approximately one-quarter of the global population. Recently, the host-gut microbiota metabolic interaction has emerged as a unique mechanistic pathway involved in the development of NAFLD. Researchers have reported a group of gut microbiota-modified bile acids, specifically hyodeoxycholic acid (HDCA), that are negatively correlated with the presence and severity of NAFLD. HDCA treatment has been shown to mitigate NAFLD in various mouse models by inhibiting intestinal farnesoid X receptor (FXR) and upregulating hepatic CYP7B1. Furthermore, HDCA significantly increased the abundance of beneficial microbial species like Parabacteroides distasonis, which enhanced lipid breakdown metabolism through the activation of peroxisome proliferator-activated receptor alpha (PPARα) signaling and, in turn, upregulated hepatic FXR. These findings suggest the therapeutic potential of HDCA for NAFLD, with a unique mechanism of simultaneously activating hepatic CYP7B1 and PPARα.

Top 5

Article Title: Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism

Journal Name: Cell Metab

Impact Factor: 29

CUSABIO Citation Product: Mouse Epinephrine/Adrenaline,EPI ELISA Kit,CSB-E08679m


"Neddylation" is a post-translational mechanism that involves the addition of a ubiquitin-like protein called Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8). Research has revealed that inhibiting neddylation reduces the gluconeogenic capacity of mouse livers and their response to hyperglycemic hormones. Additionally, individuals with type 2 diabetes display elevated levels of hepatic neddylation. Mechanistically, fasting or calorie restriction in mice leads to the neddylation of the Phosphoenolpyruvate Carboxykinase 1 (PCK1) protein, which reduces its gluconeogenic activity. Molecular dynamics simulations indicate that neddylation of PCK1 alters its conformation, increasing accessibility to its catalytic center. This study elucidates the mechanism by which neddylation regulates glucose metabolism, connecting overall nutrient supply with metabolic balance.

Top 6

Article Title: Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid

Journal Name: Nat Microbiol

Impact Factor: 28.2

CUSABIO Citation Product: Mouse Lipopolysaccharides(LPS) ELISA Kit,CSB-E13066m


This study investigates the beneficial effects of dietary fiber on non-alcoholic steatohepatitis (NASH) in mice, with a specific focus on elucidating the role of gut microbiota in this process. The research reveals that soluble fiber, such as pectin, is more effective at inhibiting NASH in mice compared to insoluble cellulose fiber. Parabacteroides distasonis, a microbe in the gut, utilizes pectin to produce adipic acid, which has a protective effect against NASH. This is achieved by restoring intestinal barrier function, reducing serum lipopolysaccharides, and decreasing the expression of hepatic inflammatory factors. These findings highlight the mechanism by which gut microbiota can utilize dietary fiber to generate beneficial metabolites, thereby suppressing metabolic diseases.

Top 7

Article Title: Clinical and pathogenic significance of S100A4 overexpression in systemic sclerosis

Journal Name: Ann Rheum Dis

Impact Factor: 24.7

CUSABIO Citation Product: Human Protein S100-A4(S100A4) ELISA kit,CSB-EL020632HU


This study aims to investigate the role of S100A4 damage-associated molecular pattern protein in activating fibroblasts in systemic sclerosis (SSc). The research found that S100A4 concentrations in the serum of SSc patients were higher than those in healthy control groups and were associated with SSc-related interstitial lung disease and scleroderma renal crisis. In cultured SSc dermal fibroblasts, the expression of S100A4 was also increased. The study revealed that recombinant S100A4 and high-affinity anti-S100A4 neutralizing monoclonal antibodies had an impact on SSc fibroblasts. Furthermore, S100A4 led to the upregulation of fibrosis-related genes in normal fibroblasts, which are commonly observed in SSc. Collectively, the research results suggest that S100A4 plays a pro-fibrotic role in SSc, and its serum levels could serve as a biomarker for organ damage and disease severity. Therefore, this study supports the therapeutic potential of targeting S100A4 for the treatment of SSc.

Top 8

Article Title: An Image-Based High-Throughput and High-Content Drug Screening Method Based on Microarray and Expansion Microscopy

Journal Name: ACS Nano

Impact Factor: 17.1

CUSABIO Citation Product:
TUBA1A Monoclonal Antibody,CSB-MA754656A0m
TOMM20 Antibody,CSB-PA618983ESR2HU


With the growing number of potential drug targets and the time it takes to evaluate them, there's a need for a more efficient drug screening method. So far, combining high-throughput and high-content in image-based drug screening has been a challenge. This study introduced an efficient approach by using superhydrophobic microarray plates (SMAPs) and a technique called protein retention expansion microscopy (proExM).

They used a flexible method to make SMAPs and cultured cells on them. Different drugs were tested on these plates, and then they used proExM to capture high-resolution images. In a demonstration, they successfully captured detailed images of microtubules within 3 hours. This approach combines high-throughput and high-content effectively, making drug screening more efficient.

Top 9

Article Title: Self-anticoagulant sponge for whole blood auto-transfusion and its mechanism of coagulation factor inactivation

Journal Name: Nat Commun

Impact Factor: 16.6

CUSABIO Citation Product: Human D-Dimer,D2D ELISA Kit,CSB-E05175h


During surgeries, autologous blood transfusions are commonly used, but they dilute the blood and affect clotting. In this study, researchers developed a special sponge that naturally absorbs blood and prevents clotting. This sponge works by deactivating certain clotting factors in the blood.

When this treated blood is used for transfusion, it helps stop bleeding faster compared to regular heparin-treated blood. This study not only introduces a safer way to use your own blood during surgery but also explains how the sponge works to prevent clotting.

Top 10

Article Title: MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis

Journal Name: Nat Commun

Impact Factor: 16.6

CUSABIO Citation Product: Mouse Testosterone,T ELISA Kit,CSB-E05101m


Human MutT Homolog 1 (MTH1) is a nucleotide library sterilizing enzyme that hydrolyzes oxidized nucleotides to prevent their incorrect incorporation into DNA in response to oxidative stress. The expression and functional role of MTH1 in platelets is unknown. In this paper, researchers show that MTH1 expression in platelets is defective and impairs hemostasis and arterial/venous thrombosis in vivo. MTH1 deficiency reduces platelet aggregation, phosphatidylserine exposure, and calcium mobilization induced by thrombin but not collagen-related peptide (CRP), along with reduced mitochondrial ATP production. Thrombin but not CRP induces Ca2+-dependent mitochondrial reactive oxygen species production. Mechanistically, MTH1 deficiency leads to oxidative damage to mitochondrial DNA and reduced expression of cytochrome C oxidase 1. In addition, MTH1 plays a similar role in human platelet function. Our study demonstrates that MTH1 exerts a protective effect against platelet oxidative stress and suggests that MTH1 may be a potential therapeutic target for the prevention of thrombophilia.