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ADC Target Surges Globally: CD33, HER2, CD22, PDL1, CLDN18.2, GUCY2C, SEMA4D, GPRC5D, CXCR4, MUC17...

In 2023, it may be a year of outbreak for Antibody-Drug Conjugates (ADC). Many ADC targets have achieved clinical breakthroughs. As of now, a total of 15 ADC drugs have been approved for marketing worldwide, with more than 140 varieties in clinical trials. ADC approach was designed to incorporate antibodies and cytotoxic molecules, which could increase the effectiveness of chemotherapy and reduce its toxicity.

CUSABIO presents a series of ADC highly potent target products to fully support your research:

ADC targets approved:

CD33, CD30, HER2, CD22, Nectin-4, BCMA, EGFR, CD19.

ADC clinically validated targets:

EGFR, CLDN18.2, TROP2, c-Met, CD19, PSMA, Muc1, PDL1.

ADC potent targets (See the table below for details):

ASGR1, ANGPT2, CD93, CXCR4, CCR4, CLDN9, GPRC5D, MUC17, SEMA4D, GUCY2C, SSTR2, PROM1, SLC39A6, TPBG, TMEFF2, VSIG4, ZG16B

Select Scenarios from Varied Experiments

● High purity verified by SDS-PAGE

The purity of human CD22 (Cat. No. CSB-MP004900HU) was more than 94% verified by SDS-PAGE.

The purity of human CD33 (Cat. No. CSB-MP004925HU) was more than 95% verified by SDS-PAGE.

The purity of human GUCY2C (Cat. No. CSB-MP010053HUd9) was more than 94.8% verified by SDS-PAGE.

The purity of human SEMA4D (Cat. No. CSB-MP835707HUd9) was more than 95% verified by SDS-PAGE.

● High bioactivity verified by functional ELISA

Immobilized human ERBB2 (Cat. No. CSB-MP007763HU) at 2 μg/mL can bind Trastuzumab, the EC50 is 2.179-2.825 ng/mL.

Immobilized human MET (Cat. No. CSB-MP013714HU) at 2 μg/mL can bind Anti-MET recombinant antibody, the EC50 is 2.379-3.094 ng/mL.

Immobilized human CXCR4 (Cat. No. CSB-MP006254HU(F1)) at 10 μg/ml can bind Anti-CXCR4 recombinant antibody, the EC50 is 101.7-253.6 ng/mL.

Immobilized human GPRC5D (Cat. No. CSB-MP882153HU) at 5 μg/mL can bind Anti-GPRC5D recombinant antibody, the EC50 is 8.847-10.38 ng/mL.

● High affinity validated by LSPR

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (Cat. No. CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (Cat. No. CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

ADC Potent Targets

Target Product Name Code Express system Tag Info
ANGPT2 Recombinant Human Angiopoietin-2(ANGPT2) (Active) CSB-MP001707HU(A4) Mammalian cell C-terminal 10xHis-tagged
ASGR1 Recombinant Rat Asialoglycoprotein receptor 1(Asgr1),partial CSB-MP002207RA1 Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
CCR4 Recombinant Human C-C chemokine receptor type 4(CCR4)-VLPs (Active) CSB-MP004843HU Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
CD20 Recombinant Human B-lymphocyte antigen CD20(MS4A1)-VLPs (Active) CSB-MP015007HU Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
CD22 Recombinant Human B-cell receptor CD22(CD22),partial (Active) CSB-MP004900HU Mammalian cell C-terminal 6xHis-tagged
CD93 Recombinant Human Complement component C1q receptor(CD93),partial (Active) CSB-MP865099HU Mammalian cell C-terminal 10xHis-tagged
CEA Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5(CEACAM5)(E398K),partial (Active) CSB-MP005165HU Mammalian cell C-terminal?10xHis-tagged
CLDN3 Recombinant Human Claudin-3(CLDN3)-VLPs (Active) CSB-MP005505HU Mammalian cell C-terminal 10xHis-tagged
CLDN4 Recombinant Human Claudin-4(CLDN4)-VLPs (Active) CSB-MP005506HU Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
CLDN6 Recombinant Human Claudin-6(CLDN6)-VLPs (Active) CSB-MP005508HU(A4) Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
CLDN9 Recombinant Human Claudin-9(CLDN9)-VLPs (Active) CSB-MP005511HU Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
CXCR4 Recombinant Human C-X-C chemokine receptor type 4(CXCR4)-VLPs (Active) CSB-MP006254HU(F1) Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
DDR1 Recombinant Human Epithelial discoidin domain-containing receptor 1(DDR1),partial (Active) CSB-MP006595HU Mammalian cell C-terminal 10xHis-tagged
DT3C Recombinant DT3C protein CSB-EP360556CQR1 E.coli N-terminal 6xHis-tagged
GPRC5D Recombinant Human G-protein coupled receptor family C group 5 member D(GPRC5D)-VLPs (Active) CSB-MP882153HU Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
GUCY2C Recombinant Human Heat-stable enterotoxin receptor(GUCY2C),partial (Active) CSB-MP010053HUd9 Mammalian cell C-terminal hFc-tagged
MUC17 Recombinant Human Mucin-17(MUC17),partial (Active) CSB-MP727848HU Mammalian cell C-terminal?10xHis-tagged
PROM1 Recombinant Human Prominin-1(PROM1)-VLPs (Active) CSB-MP018751HU(A4) Mammalian cell C-terminal?10xHis-tagged (This tag can be tested only under denaturing conditions)
SEMA4D Recombinant Human Semaphorin-4D(SEMA4D),partial (Active) CSB-MP835707HUd9 Mammalian cell C-terminal hFc-tagged
SLC39A6 Recombinant Human Zinc transporter ZIP6(SLC39A6),partial (Active) CSB-BP621669HU1 Baculovirus C-terminal 6xHis-tagged
SSTR2 Recombinant Human Somatostatin receptor type 2(SSTR2)-VLPs (Active) CSB-MP022725HU Mammalian cell C-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
TMEFF2 Recombinant Human Tomoregulin-2(TMEFF2),partial (Active) CSB-MP883439HU Mammalian cell C-terminal 10xHis-tagged
TPBG Recombinant Human Trophoblast glycoprotein(TPBG),partial (Active) CSB-MP024093HUb0 Mammalian cell N-terminal?10xHis-tagged
VSIG4 Recombinant Human V-set and immunoglobulin domain-containing protein 4(VSIG4),partial (Active) CSB-MP896869HU Mammalian cell C-terminal 10xHis-tagged
ZG16B Recombinant Human Zymogen granule protein 16 homolog B(ZG16B) (Active) CSB-MP836195HU Mammalian cell C-terminal 10xHis-tagged

ADC Favored Products

Target Product Name Code Source Tag Info
ALCAM Recombinant Human CD166 antigen(ALCAM),partial CSB-EP614444HU E.coli N-terminal 6xHis-SUMO-tagged
CD22 Recombinant Human B-cell receptor CD22(CD22),partial (Active) CSB-MP004900HU Mammalian cell C-terminal 6xHis-tagged
CD276 Recombinant Human CD276 antigen(CD276),partial (Active) CSB-MP733578HU Mammalian cell C-terminal hFc-Myc-tagged
CD33 Recombinant Human Myeloid cell surface antigen CD33(CD33),partial (Active) CSB-MP004925HU Mammalian cell C-terminal hFc-Myc-tagged
CD46 Recombinant Human Membrane cofactor protein(CD46) (Active) CSB-MP004939HU Mammalian cell C-terminal hFc-tagged
CLDN18 Recombinant Human Claudin-18.2(CLDN18.2)-VLPs (Active) CSB-MP005498HU(A5) Mammalian cell C-terminal 10xHis-tagged
DLL3 Recombinant Human Delta-like protein 3(DLL3),partial (Active) CSB-MP882142HU Mammalian cell C-terminal 6xHis-tagged
DLL3 Recombinant Macaca fascicularis Delta-like protein 3(DLL3),partial (Active) CSB-MP3536MOV Mammalian cell C-terminal 6xHis-tagged
EGFR Recombinant Human Epidermal growth factor receptor(EGFR),partial (Active) CSB-MP007479HU Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
ERBB2 Recombinant Human Receptor tyrosine-protein kinase erbB-2(ERBB2),partial (Active) CSB-MP007763HU Mammalian cell C-terminal 6xHis-tagged
ERBB3 Recombinant Human Receptor tyrosine-protein kinase erbB-3(ERBB3),partial (Active) CSB-MP007765HU Mammalian cell C-terminal hFc-tagged
MET Recombinant Human Hepatocyte growth factor receptor(MET),partial (Active) CSB-MP013714HU Mammalian cell C-terminal hFc-tagged
MS4A1 Recombinant Human B-lymphocyte antigen CD20(MS4A1)-VLPs (Active) CSB-MP015007HU Mammalian cell C-terminal 10xHis-tagged
MSLN Recombinant Human Mesothelin(MSLN),partial (Active) CSB-MP015044HUc9 Mammalian cell N-terminal hFc-tagged
NCAM1 Recombinant Human Neural cell adhesion molecule 1(NCAM1),partial CSB-EP015511HU1 E.coli N-terminal 6xHis-tagged
NECTIN4 Recombinant Human Nectin-4(NECTIN4),partial (Active) CSB-MP822274HU Mammalian cell C-terminal 10xHis-tagged
ROR1 Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1(ROR1),partial (Active) CSB-MP020067HU1d7 Mammalian cell C-terminal 10xHis-tagged
TACSTD2 Recombinant Human Tumor-associated calcium signal transducer 2(TACSTD2),partial (Active) CSB-MP023072HU1 Mammalian cell C-terminal hFc-tagged
TDGF1 Recombinant Human TeRatocarcinoma-derived growth factor 1(TDGF1),partial CSB-EP023343HU1e0 E.coli N-terminal GST-tagged
TNF Recombinant Human Tumor necrosis factor(TNF),partial (Active) CSB-EP023955HUc7 E.coli C-terminal 6xHis-tagged
TNFRSF10B Recombinant Human Tumor necrosis factor receptor superfamily member 10B(TNFRSF10B),Partial (Active) CSB-AP002291HU E.coli Tag-Free
TNFRSF17 Recombinant Human Tumor necrosis factor receptor superfamily member 17(TNFRSF17),partial (Active) CSB-MP023974HU1 Mammalian cell C-terminal hFc-tagged
TNFSF8 Recombinant Human Tumor necrosis factor ligand superfamily member 8(TNFSF8),partial (Active) CSB-MP023996HU1 Mammalian cell N-terminal 6xHis-tagged
TNFSF8 Recombinant Human Tumor necrosis factor ligand superfamily member 8(TNFSF8),partial (Active) CSB-MP023996HU1c9 Mammalian cell N-terminal hFc-tagged

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