News

You Made the RNA. Now How Do You Deliver It to ...

LNP · IONIZABLE LIPID · mRNA · siRNA · NUCLEIC ACID DELIVERY You Made the RNA. Now How Do You Deliver It to the Cytoplasm? For mRNA and siRNA therapeutics,...

Designing a PROTAC? Start by Choosing the Right...

TARGETED PROTEIN DEGRADATION · PROTAC · CRBN · MOLECULAR GLUE Designing a PROTAC? Start by Choosing the Right CRBN Ligand Handle PROTAC design requires more than selecting a target binder...

You Measured Your AAV Titer. But What Did You A...

AAV · GENE THERAPY · VECTOR QC · ELISA · ddPCR You Measured Your AAV Titer. But What Did You Actually Measure? AAV titer is not a single measurement. Capsid...

Beyond Linear Epitopes: Why Molecular Context M...

CARDIAC BIOMARKERS · cTnI · IMMUNOASSAY DEVELOPMENT Beyond Linear Epitopes: Why Molecular Context Matters in Cardiac Troponin Detection Cardiac troponin I is a critical biomarker of myocardial injury, but circulating...

Polysorbate 80 in Biologic Formulation: Why Exc...

BIOPHARMA FORMULATION · EXCIPIENT · POLYSORBATE 80 Polysorbate 80 in Biologic Formulation: Why Excipient Purity Matters Polysorbate 80 is widely used as a nonionic surfactant in pharmaceutical formulations. For biologics,...

More Payload Isn't Always Better: Managing Hydr...

ADC · LINKER CHEMISTRY · POLYSARCOSINE · BIOCONJUGATION More Payload Isn't Always Better: Managing Hydrophobicity in High-DAR ADCs with pSar Increasing drug-to-antibody ratio can increase the amount of payload carried...