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Your Compound Inhibits the Kinase In Vitro. But...

DRUG DISCOVERY · KINASE SCREENING · NanoBRET Your Compound Inhibits the Kinase In Vitro. But Does It Actually Work Inside the Cell? A single IC50 value rarely tells the complete...

Antibody Function Is More Than Amino Acid Seque...

ANTIBODY ENGINEERING · Fc GLYCOSYLATION · BIOANALYSIS Antibody Function Is More Than Amino Acid Sequence: Understanding Fc Glycosylation and Glycoengineering Two antibodies with the same amino acid sequence may not...

From PCR Strips to 2 mL Microtubes: What Should...

LAB EQUIPMENT · CENTRIFUGATION · PCR / qPCR From PCR Strips to 2 mL Microtubes: What Should You Look for in a Mini Centrifuge? Quick spin-down steps occur throughout DNA/RNA...

Reducing Background in Multiplex Immunofluoresc...

IMMUNOFLUORESCENCE · MULTIPLEX IMAGING · CHICKEN IgY Reducing Background in Multiplex Immunofluorescence: Why Chicken IgY Antibodies Can Expand Your Panel As multiplex imaging panels become more complex, primary antibody host...

Lactate Is More Than a Metabolic Byproduct: Exp...

POST-TRANSLATIONAL MODIFICATIONS · METABOLISM · PROTEOMICS Lactate Is More Than a Metabolic Byproduct: Exploring Lysine Lactylation in Metabolism and Cell Regulation Lysine lactylation (Kla) is emerging as an intriguing post-translational...

Beyond the Matrix: Why Animal-Origin-Free N2 an...

CELL CULTURE · ORGANOIDS · STEM CELLS Beyond the Matrix: Why Animal-Origin-Free N2 and B27 Supplements Matter in 3D Cell Culture Reproducible organoid and stem cell culture depends on more...