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Coagulation factors are a group of proteins synthesized by the liver that play a vital role in the blood clotting process. When blood vessels are injured, these factors activate sequentially through a cascade reaction, ultimately leading to the formation of fibrin networks that seal wounds.
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Classification and Function
| 13 major coagulation factors (I-XIII) designated by Roman numerals are found in the human body.Coagulation factors are a group of proteins involved in the blood clotting process, primarily dependent on vitamin K in the liver for synthesis. Deficiencies in factor VIII and IX cause hemophilia A and B respectively. Abnormal coagulation can lead to bleeding or thrombotic disorders, with treatments including plasma products, recombinant factors, or anticoagulant medications, classified by function as follows: |
Fibrin-Related Factors：Factor I(Fibrinogen), Factor XIII(Fibrin-Stabilizing Factor)
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Cofactors ：Factors V,VIII, Factor III(Tissue Factor)
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Calcium lons (Factor IV):
Act as a bridge between phospholipid surfaces and coagulation factors, ensuring spatial coordination of reactions
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How to identify ？
| FineTest® has developed a series of ELISA Kits to support scientific researchers in their research on Blood Coagulation Factors . |
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Principle：
The enzyme-labeled plate was coated with specific antibodies for each subtype, and the color reaction was detected by enzyme-labeled secondary antibody after the target antibody in the sample was bound.
Advantages:
High sensitivity, simultaneous detection of multiple subtypes, and relatively simple operation.
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