In biologics and advanced therapy workflows, monitoring residual DNA is an important part of impurity assessment. Residual host cell DNA may remain after purification and must be carefully evaluated.
Why It Matters
- Supports product safety assessment
- Helps optimize purification workflows
- Provides important quality data
Common Detection Methods
- qPCR assays
- Digital PCR
- DNA-binding fluorescence assays
qPCR-based residual DNA detection is widely used because it offers high sensitivity and specificity.