Multiclonal Antibodies
Polyclonal Sensitivity with Recombinant Precision
Multiclonal antibodies are defined mixtures of recombinant monoclonal antibodies, with each clone selected to recognize a distinct epitope on the same target. The result is broad, multi-epitope recognition combined with the reproducibility and consistency expected from recombinant antibodies.
What Is a Multiclonal Antibody?
Traditional polyclonal antibodies recognize multiple epitopes and can provide strong signal and high sensitivity. However, animal-derived antisera contain heterogeneous antibody populations that may vary between production lots.
A multiclonal antibody provides a controlled alternative. It combines multiple individually defined recombinant monoclonal antibodies, each recognizing a different epitope on the same antigen.
Because each clone is sequence-defined, the antibody mixture can be reproduced consistently while retaining the advantages of multi-epitope target recognition. This makes multiclonal antibodies particularly attractive for researchers who want both strong detection performance and improved long-term reproducibility.
Why Choose Multiclonal Antibodies?
Multi-Epitope Detection
Multiple recombinant antibodies recognize different epitopes on the target, supporting strong and reliable signal generation.
Consistent Performance
Sequence-defined recombinant clones provide excellent lot-to-lot consistency and support reproducible results across long-term research projects.
Animal-Free Development
Featured multiclonal secondary antibodies are generated using phage display technology without animal immunization.
Workflow Compatibility
Multiclonal antibodies can fit into common workflows including WB, ELISA, IF, ICC, IHC and flow cytometry.
Polyclonal vs. Monoclonal vs. Multiclonal
Multiclonal antibodies are designed to combine the broad epitope recognition commonly associated with polyclonal antibodies with the defined composition and consistency of recombinant monoclonal antibodies.
| Feature | Polyclonal | Monoclonal | Multiclonal |
|---|---|---|---|
| Epitope Recognition | Multiple | Single | Multiple |
| Composition Defined | No | Yes | Yes |
| Batch Consistency | Variable | High | High |
| Long-Term Reproducibility | Moderate | High | High |
| Multi-Epitope Signal | Yes | No | Yes |
Built for the Workflows You Already Use
Multi-epitope recognition can be especially useful when working with low-abundance targets or experimental conditions in which individual epitopes may be masked, altered or affected by protein denaturation.
By recognizing several epitopes rather than relying on a single binding site, multiclonal antibodies can offer additional robustness across different sample preparation and detection conditions.
Featured Multiclonal Secondary Antibodies
Recombinant · Mouse Host · Animal-Free · Unconjugated / HRP / Alexa Fluor 555 / Alexa Fluor 488
| Target | Conjugate | Catalog No. |
|---|---|---|
| Mouse anti-Rabbit IgG | Unconjugated | ABIN7581783 |
| HRP | ABIN7581784 | |
| Alexa Fluor 555 | ABIN7581785 | |
| Alexa Fluor 488 | ABIN7581786 | |
| Mouse anti-Goat IgG | Unconjugated | ABIN7581787 |
| HRP | ABIN7581788 | |
| Alexa Fluor 555 | ABIN7581789 | |
| Alexa Fluor 488 | ABIN7581790 | |
| Mouse anti-Human IgG (Fc Region) | Unconjugated | ABIN7581782 |
| HRP | ABIN7581791 | |
| Alexa Fluor 555 | ABIN7581792 | |
| Alexa Fluor 488 | ABIN7581793 |
Choosing the Right Conjugate
The appropriate conjugate depends primarily on your detection workflow.
A convenient option for chemiluminescent or colorimetric Western blot and ELISA workflows.
Suitable for fluorescence-based imaging and flow cytometry applications requiring green fluorescence detection.
A fluorescence option for imaging and multi-color detection workflows.
Appropriate for researchers requiring custom labeling, conjugation, or specialized assay development.
Not Sure Which Antibody Fits Your Experiment?
Antibody selection often depends on more than the target alone. Primary antibody species, detection method, sample type, assay format and fluorescence requirements can all affect product selection.
Send Dana Bioscience your target, primary antibody species, application, preferred conjugate or catalog number, and we can help identify the appropriate multiclonal secondary antibody for your workflow.
Need Help Selecting a Multiclonal Antibody?
Send us your target, primary antibody species, application, or catalog number. Dana Bioscience can help identify the appropriate reagent and provide pricing and availability for your research.
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Products are intended for research use only. Product specifications and suitability should be confirmed for the intended experimental conditions.