Adeno-associated virus (AAV) has become the leading viral vector platform for in vivo gene therapy. As gene therapy programs continue to expand across neurology, ophthalmology, oncology, and rare disease applications, researchers require reliable tools for vector characterization, identity testing, neutralization studies, and assay development.
AntibodySystem provides a comprehensive portfolio of AAV antibodies, recombinant proteins, and ELISA reagents covering major serotypes including AAV1–AAV9 as well as engineered variants such as DJ, rh74, and rh.1.
Why AAV Matters in Modern Gene Therapy
AAV vectors are widely used because of their favorable safety profile, long-term gene expression, and tissue-specific tropism. Different AAV serotypes preferentially target different tissues, making serotype selection a critical component of gene therapy design.
- Brain: AAV1, AAV2, AAV2/DJ, AAV2/DJ8, AAV2g9, AAV2-retro, scAAV9
- Muscle: AAV6, AAV8, AAV9
- Retina: AAV1, AAV2, AAV5, AAV8, AAV9
- Heart: AAV9, AAV rh74
- Lung: AAV9
- Liver: AAV8
AntibodySystem AAV Portfolio Overview
- Coverage of 9+ AAV serotypes
- AAV1–AAV9 plus DJ, rh74 and rh.1 variants
- VP1, VP2 and VP3 capsid targets
- Intact-particle and conformational capsid antibodies
- Monoclonal, polyclonal and InVivoMAb formats
- Neutralizing antibodies for functional studies
- Recombinant proteins for assay development
Applications
AntibodySystem AAV reagents support a broad range of research and analytical workflows:
- AAV titer determination
- Capsid identity testing
- Neutralizing antibody assays
- ELISA development
- Western Blot
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Flow Cytometry
- CLIA and Lateral Flow Assays
- Surface Plasmon Resonance (SPR)
Featured Products
| Catalog No. | Product | Applications |
|---|---|---|
| RVV16803 | Anti-AAV2 Capsids (intact particle) Antibody (A20R) | Dot Blot, ELISA, ICC/IF, IP, Neutralization |
| RVV46701 | Anti-AAV9 VP1/Capsid Protein VP1 Antibody (SAb2392) | ELISA, WB, IFA, IHC, CLIA, LFA, IP |
| RVV48201 | Anti-AAV8 (intact particle) Antibody (SAb2452) | ELISA, Neutralization |
| RVV16810 | Anti-AAV1/2/5/6/8/9/DJ/rh.1 VP1/2/3 Antibody | ELISA, WB |
| RVV46704 | Anti-AAV9 Antibody (Fs0365) | ELISA, Neutralization |
Advantages of AntibodySystem AAV Reagents
- Broad serotype coverage across commonly used therapeutic vectors
- Validated antibodies for both capsid proteins and intact particles
- Neutralizing antibodies for in vivo and functional studies
- Matched antibody-antigen pairs for ELISA development
- Comprehensive datasheets and validation data
- Worldwide delivery and research-use-only support
Request Product Information
Dana Bioscience supplies AntibodySystem products worldwide for research applications. Contact us for quotations, technical support, datasheets, and distributor inquiries.